A nationwide study of Stevens–Johnson syndrome and toxic epidermal necrolysis in hospitalized pregnant women in the United States, 2009–2020Capsule Summary

Autor: Paul Wasuwanich, BSc, Robert S. Egerman, MD, Tony S. Wen, MD, Kiran Motaparthi, MD
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: JAAD International, Vol 16, Iss , Pp 175-182 (2024)
Druh dokumentu: article
ISSN: 2666-3287
DOI: 10.1016/j.jdin.2024.04.002
Popis: Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rarely described in the pregnant population, and knowledge of their impact on the mother/fetus is limited. Objective: To describe SJS/TEN in pregnant women and to investigate the risk factors for developing SJS/TEN in pregnancy. Methods: We utilized hospitalization data from the 2009–2020 National Inpatient Sample. Pregnancy hospitalizations and SJS/TEN involvement were identified by ICD-9/10 codes and analyzed by chi-square and logistic regression. Results: We identified 650 pregnancies complicated by SJS/TEN requiring hospitalization. The median age was 28 years, and most were non-Hispanic White (55.2%). There were ≤10 cases associated with mortality. Most SJS/TEN cases (73.9%) occurred during the third trimester. HIV infection (OR = 9.49; P = .030), herpes simplex virus infection (OR = 2.49; P = .021), genitourinary tract infections (OR = 3.80; P
Databáze: Directory of Open Access Journals