Frequency and Association of Polymorphisms in F2, F7, and PROS1 Coagulation Genes with Disease Severity in Coronavirus Disease 2019

Autor: Dalal Sulaiman Alshaya PhD, Lama A. Alzamil BSc, Alanoud S. Alghamdi BSc, Lolwah S. Alshammari BSc, Saltana A. Alhowaiti BSc, Marie Fe F. Bohol BSc, Esra’a Abudouleh PhD, Fatimah Alhamlan PhD, Arwa A. Al-Qahtani MD, Amal Al Hazzani PhD, Tarek Owaidah MD, Ahmed A. Al-Qahtani PhD
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Clinical and Applied Thrombosis/Hemostasis, Vol 30 (2024)
Druh dokumentu: article
ISSN: 1938-2723
10760296
DOI: 10.1177/10760296241295731
Popis: Abnormal transcriptomic profiles of coagulation genes have been linked to coagulopathies in patients with coronavirus disease 2019 (COVID-19). The objective of the present study was to explore the frequency of genotypes and potential association of polymorphisms in genes encoding coagulation factors with the disease severity in COVID-19 patients. The patients were clinically categorized into four groups of COVID-19 disease severity (asymptomatic, mild, moderate, and severe). Three variants of genes, involving the coagulation genes rs3136516 (F2 gene), rs6042 (F7 gene), and rs6123 (PROS1 gene), were studied. Polymorphisms were genotyped by Sanger DNA sequencing. Most of the subjects had moderate COVID-19 infection (n = 53, 62.4%), followed by mild (n = 16, 18.8%), and severe infections (n = 15, 17.6%). The frequency of the rs3136516 AG genotype was considerably higher in non-ICU patients compared to ICU patients (51.3% vs 34.1%, OR 3.167, 95% CI 1.094-9.170, P = .031). Furthermore, the dominant genetic model (AA + AG vs GG) was significantly associated with a decreased probability of admission to the ICU in COVID-19 patients (OR 0.340, 95% CI 0.127 - 0.905, and P = .028). No other variants of the coagulation genes studied were found to be associated with the severity of COVID-19 disease, admission to the ICU, and mortality ( P > .05). The rs3136516 AG genotype could predispose COVID-19 patients to increased disease severity and therefore admission to the ICU, while the dominant genetic model (AA + AG vs GG) of rs3136516 exerts a protective role.
Databáze: Directory of Open Access Journals
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