Association of insulin resistance indexes to carotid intima-media thickness.

Autor: Angela Sciacqua, Maria Adelaide Marini, Marta Letizia Hribal, Francesco Perticone, Giorgio Sesti
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: PLoS ONE, Vol 8, Iss 1, p e53968 (2013)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0053968
Popis: OBJECTIVES: Accumulating evidence suggests an association between insulin resistance (IR) and cardiovascular diseases The aim of this study was to examine the relationship between indexes of IR and common carotid intima-media thickness (IMT), an indicator of vascular damage. METHODS: In 847 non-diabetic Caucasians a 75 g oral glucose tolerance test was performed and surrogate indexes of IR were computed according to published formulas. IMT was measured by ultrasound method. RESULTS: The Stumvoll ISI(OGTT) index was correlated with IMT more strongly than the other indexes of IR. The IR indexes correlated significantly (P0.9 mm, for the Stumvoll ISI(OGTT) index was significantly higher (0.710) as compared with the AUCs of Matsuda (0.642) (P = 0.0009), OGIS (0.666) (P = 0.04), HOMA (0.611) (P
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