Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccination

Autor:	Tanja Lövgren, Maria Wolodarski, Stina Wickström, Ulrika Edbäck, Mette Wallin, Eva Martell, Katrin Markland, Pontus Blomberg, Maria Nyström, Andreas Lundqvist, Hans Jacobsson, Gustav Ullenhag, Per Ljungman, Johan Hansson, Giuseppe Masucci, Roger Tell, Isabel Poschke, Lars Adamson, Jonas Mattsson, Rolf Kiessling
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	combination immunotherapy adoptive tumor-infiltrating lymphocyte therapy tumor lysate dc vaccination immune checkpoint inhibitor resistance Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 9, Iss 1 (2020)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2020.1792058
Popis:	Development of T cell-directed immune checkpoint inhibitors (ICI) has revolutionized metastatic melanoma (MM) therapy, but 36 and >18 months, respectively). In addition, two patients had partial responses (PR), one still ongoing (>42 months) with only a small bone-lesion remaining, and one of short duration (
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3663da887a2248c99067afb3cb7e27eb Zobrazit plný text záznamu View record in DOAJ