Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania

Autor: Edita Kunceviciene, Margarita Sriubiene, Rasa Liutkeviciene, Ilona T. Miceikiene, Alina Smalinskiene
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Ophthalmology, Vol 18, Iss 1, Pp 1-6 (2018)
Druh dokumentu: article
ISSN: 1471-2415
DOI: 10.1186/s12886-018-0787-1
Popis: Abstract Background This study aimed to assess heritability of myopia in Lithuania and evaluate both genes GJD2 (Gap Junction Protein, Delta 2) and RASGRF1 (RAS protein-specific guanine nucleotide-releasing factor 1) relation with myopia. Methods In this study Lithuanian twin population aged between 18 and 40 (n = 460) were examined. Single-nucleotide polymorphisms of the RASGRF1 (rs8027411) and GJD2 (rs634990) genes were assessed by real-time polymerase chain reaction method. Results Intrapair correlations for spherical equivalent in all twin pairs were significantly higher in MZ twin pairs r = 0.539 (p 0.05, 95% CI -0.215-0.381) and in DZ twin pairs r = − 0.220 (p > 0.05, 95% CI -0.587-0.222). The odds ratio (95% CI) were 2.7 (1.018–7.460) for combinations of genotypes of rs634990 CC and rs8027411 GT (p = 0.046). Conclusions Our studies have shown that the heritability of myopia makes 67.2% in Lithuania. Persons with combinations of genotypes rs634990 CC and rs8027411 GT have 2.7 times higher odds to have myopia.
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