Clinical Outcomes of Adult Patients Hospitalized with COVID-19 after Vaccination

Autor: Markos Kalligeros, Fadi Shehadeh, Evangelia K. Mylona, Matthew Kaczynski, Saisanjana Kalagara, Eleftheria Atalla, Maria Tsikala Vafea, Eleftherios Mylonakis
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Tropical Medicine and Infectious Disease, Vol 6, Iss 4, p 175 (2021)
Druh dokumentu: article
ISSN: 2414-6366
DOI: 10.3390/tropicalmed6040175
Popis: Vaccination remains the most effective way to prevent COVID-19. The aim of the present study was to assess the incidence of COVID-19 hospitalizations after vaccination, as well as the effect of prior vaccination on hospitalization outcomes among patients with COVID-19. We analyzed and compared all consecutive patients, with or without prior vaccination, who were admitted to our hospital network due to COVID-19 from January to April 2021. Our primary outcome was to identify and describe cases of COVID-19 hospitalized after vaccination. We also utilized a multivariate logistic regression model to investigate the association of previous vaccination with hospitalization outcomes. We identified 915 consecutive patients hospitalized due to COVID-19 with 91/915 (10%) previously vaccinated with at least one dose of a COVID-19 vaccine. Utilizing our multivariate logistic regression model, we found that prior vaccination, regardless of the number of doses or days since vaccination, was associated with decreased mortality (aOR 0.44, 95% CI: 0.20–0.98) when compared to unvaccinated individuals. Our study showed that COVID-19 related hospitalization after vaccination may occur to a small percentage of patients, mainly those who are partially vaccinated. However, our findings underline that prior vaccination, even when partial, is associated with a decreased risk of death. Ongoing vaccination efforts should remain an absolute priority.
Databáze: Directory of Open Access Journals