Stress in pregnancy - Implications for fetal BDNF in amniotic fluid at birth

Autor: Eva Kathrin Lamadé, Bruno Pedraz-Petrozzi, Ole Lindner, Pascal Meininger, Antonia Pisters, Maria Gilles, Stephanie H. Witt, Marcella Rietschel, Helene Dukal, Fabian Schunk, Michaela Coenen, Stefan A. Wudy, Rainer Hellweg, Michael Deuschle
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Neurobiology of Stress, Vol 31, Iss , Pp 100658- (2024)
Druh dokumentu: article
ISSN: 2352-2895
DOI: 10.1016/j.ynstr.2024.100658
Popis: Introduction: At the maternal-fetal interface in pregnancy, stress during pregnancy can lead to an increased vulnerability to later psychopathology of the fetus. Potential mediators of this association have scarcely been studied and may include early alterations of fetal brain-derived neurotrophic factor (BDNF). Amniotic fluid is of particular interest for effects on fetal endocrine alterations, as the assessment in amniotic fluid allows for measurements over a time integral. This study hypothesized that maternal psychometrics, socioeconomic status and glucocorticoids are related to BDNF levels in amniotic fluid at birth. The association of fetal BDNF with newborn anthropometrics was tested. Methods: Women near term who underwent elective cesarean section and their newborns were investigated (n = 37). Maternal psychometrics, socioeconomic status and glucocorticoids (the sum of cortisol and cortisone) in amniotic fluid at birth were analyzed for an association with fetal BDNF in amniotic fluid at birth. Newborn anthropometrics were assessed by length, weight, head circumference and gestational age at birth. Results: In bivariate analysis, maternal psychometrics and socioeconomic status were not related to fetal BDNF in amniotic fluid at birth. The sum of cortisol and cortisone related to increased fetal BDNF in amniotic fluid at birth (r = 0.745, p
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