In vitro anti-malarial activity of aerial part of Boenninghausenia albiflora
| Autor: | M. F Alam, M.M. Safhi, A. K. Chopra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Environment Conservation Journal, Vol 12, Iss 3 (2011) |
| Druh dokumentu: | article |
| ISSN: | 0972-3099 2278-5124 |
| DOI: | 10.36953/ECJ.2011.120302 |
| Popis: | Boenninghausenia albiflora belonging to the family Rutaceae is well known for its medicinal properties in traditional system of medicine. The crude ethanolic extracts of aerial part were tested for in-vitro anti-plasmodial activity against two strains of Plasmodium falciparum: MRC-pf-20 (chloroquine resistant strain) and MRC-pf-303 (chloroquine sensitive strain), using the parasite lactate dehydrogenase (pLDH) assay. Crude ethanolic extracts showed good anti-plasmodial activity in vitro (IC50 ≤ 50 μgml-1). It showed promising anti-plasmodial activity with an IC50 = 22.18μgml-1 on MRC-pf-20 strain and IC50 = 27.43μgml-1 on MRC-pf-303 strain. Crude ethanolic extracts were be further fractionated by partitioning in water and dichloromethane. The dichloromethane fraction revealed stronger anti-plasmodial activity than crude ethanolic extracts. The dichloromethane extract of B. albiflora showed promising anti-plasmodial activity with an IC50 = 12.32 μgml-1 on MRC-pf-20 strain and IC50 = 17.41 μgml-1 on MRC-pf-303 strain. Therefore, there is need to continue the extensive study including isolation and identification of the active compound and their invitro and invivo activity. |
| Databáze: | Directory of Open Access Journals |
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