| Autor: |
Qiankun Ji, Kai Huang, Yuan Jiang, Kunjian Lei, Zewei Tu, Haitao Luo, Xingen Zhu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cancer Medicine, Vol 11, Iss 9, Pp 2020-2035 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7634 |
| DOI: |
10.1002/cam4.4603 |
| Popis: |
Abstract Background The therapeutic effects of conventional treatment on gliomas are not promising. The tumor microenvironment (TME) has a close association with the invasiveness of multiple types of tumors, including low‐grade gliomas (LGG). This study aims to validate the prognostic and immune‐related role of macrophage scavenger receptor 1 (MSR1) in LGG patients. Methods Data in this study were obtained from public databases. The differential expression of MSR1 was analyzed in LGG patients with different clinicopathological characteristics. Kaplan–Meier survival analysis, a time‐dependent receiver operating characteristic (ROC) curve, and Cox regression analysis were used to assess the prognostic value of MSR1. Differentially expressed genes (DEGs) were screened between the high and low expression groups of MSR1. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to annotate the function of these DEGs. Hallmark gene sets were identified based on MSR1 by Gene Set Enrichment Analysis (GSEA). Difference analysis and correlation analysis were used to study the relationship between MSR1 and TME‐related scores, tumor‐infiltrating immune cells (TIICs), immune‐related gene sets, and immune checkpoints (ICPs). The single‐cell sequencing data were processed to identify the cell types expressing MSR1. The quantification of TIICs in TME was calculated by single‐sample gene set enrichment analysis (ssGSEA). The differential expression of MSR1 in LGG and control brain tissues was verified by experiments. Results There were significant differences in the expression level of MSR1 in different types of tissues and cells. MSR1 has a high prognostic value in LGG patients and can be used as an independent prognostic factor. MSR1 is closely related to TME and may play an important role in the immunotherapy of LGG patients. Conclusions The result of our study demonstrated that MSR1 is an independent prognostic biomarker in LGG patients and may play an important role in the TME of LGGs. |
| Databáze: |
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