Impact of Stroma on the Growth, Microcirculation, Metabolism of Experimental Prostate Tumors

Autor: Christian M. Zechmann, Eva C. Woenne, Gunnar Brix, Nicole Radzwill, Martin Ilg, Peter Bachert, Peter Peschke, Stefan Kirsch, Hans-Ulrich Kauczor, Stefan Delorme, Wolfhard Semmler, Fabian Kiessling
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Zdroj: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 1, Pp 57-67 (2007)
Druh dokumentu: article
ISSN: 1476-5586
1522-8002
DOI: 10.1593/neo.06688
Popis: In prostate cancers (PCa), the formation of malignant stroma may substantially influence tumor phenotype and aggressiveness. Thus, the impact of the orthotopic and subcutaneous implantations of hormone-sensitive (H), hormone-insensitive (HI), anaplastic (AT1) Dunning PCa in rats on growth, microcirculation, metabolism was investigated. For this purpose, dynamic contrast-enhanced magnetic resonance imaging and 1H magnetic resonance spectroscopy ([1H]MRS) were applied in combination with histology. Consistent observations revealed that orthotopic H tumors grew significantly slower compared to subcutaneous ones, whereas the growth of HI and AT1 tumors was comparable at both locations. Histologic analysis indicated that glandular differentiation and a close interaction of tumor cells and smooth muscle cells (SMC) were associated with slow tumor growth. Furthermore, there was a significantly lower SMC density in subcutaneous H tumors than in orthotopic H tumors. Perfusion was observed to be significantly lower in orthotopic H tumors than in subcutaneous H tumors. Regional blood volume and permeability-surface area product showed no significant differences between tumor models and their implantation sites. Differences in growth between subcutaneous and orthotopic H tumors can be attributed to tumor-stroma interaction and perfusion. Here, SMC, may stabilize glandular structures and contribute to the maintenance of differentiated phenotype.
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