Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression

Autor: Frederic Li Mow Chee, Bruno Beernaert, Billie G. C. Griffith, Alexander E. P. Loftus, Yatendra Kumar, Jimi C. Wills, Martin Lee, Jessica Valli, Ann P. Wheeler, J. Douglas Armstrong, Maddy Parsons, Irene M. Leigh, Charlotte M. Proby, Alex von Kriegsheim, Wendy A. Bickmore, Margaret C. Frame, Adam Byron
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37021-x
Popis: Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene expression.
Databáze: Directory of Open Access Journals