| Autor: |
Aude Christelle Ka'e, Maria Mercedes Santoro, Leonardo Duca, Collins Ambe Chenwi, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Naomi-Karell Etame, Willy Leroi Togna Pabo, Grace Beloumou, Marie Laure Mpouel, Sandrine Djupsa, Desire Takou, Samuel Martin Sosso, Hyppolite K. Tchidjou, Vittorio Colizzi, Gregory-Edie Halle-Ekane, Carlo-Federico Perno, Sharon Lewin, R Brad Jones, Caroline T. Tiemessen, Francesca Ceccherini-Silberstein, Joseph Fokam |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Virus Eradication, Vol 10, Iss 1, Pp 100367- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2055-6640 |
| DOI: |
10.1016/j.jve.2024.100367 |
| Popis: |
Background: With the advent of antiretroviral therapy (ART), most children living with HIV in sub-Saharan Africa (SSA) are growing toward adolescence, with scarcity of evidence on the size of viral reservoirs to enhance paediatric cure research strategies. This study aims to compare HIV-1 proviral DNA levels according to virological response among adolescents living with perinatally acquired HIV-1 (ALPHIV) and identify associated-factors in the Cameroonian context. Methods: In this observational cohort study, HIV-1 RNA viremia and CD4+ T-cell count were assessed through RT-PCR and flow cytometry respectively at three time-points over 18 months of observation. At the third time-point, 80 randomly-selected participants were classified as with viremia (≥50 HIV-1 copies/mL; n = 40) or without viremia ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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