Transcranial doppler ultrasound assessment of intracranial hemodynamics in patients with type 2 diabetes mellitus.
| Autor: | Dikanovic Marinko, Hozo Izet, Kokic Slaven, Titlic Marina, Jandric Marica, Balen Ivan, Kadojic Dragutin |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Annals of Saudi Medicine, Vol 25, Iss 6, Pp 486-488 (2005) |
| Druh dokumentu: | article |
| ISSN: | 0256-4947 0975-4466 |
| Popis: | Background: Diabetics have a 3-fold risk for cardiovascular diseases compared with non-diabetics. This study was designed to evaluate cerebral hemodynamic changes related to type 2 diabetes mellitus (DM) with transcranial Doppler ultrasonography (TCD). TCD is a highly sensitive and specific method of quick bedside assessment of cerebrovascular circulation hemodynamics. Patients and Methods: In a prospective study, we compared a group of 100 patients with the diagnosis of type 2 diabetes mellitus (aged 48 to 67 years) and an age- and sex-matched control group of 100 healthy subjects without diabetes mellitus. We measured flow velocities (Vm) and the Gosling pulsatility index (PI) of the middle cerebral artery (MCA). Results: The rate of TCD abnormalities was significantly higher in diabetic patients than in healthy control subjects (55% vs. 11%, P< 0.05). The PI was significantly higher in diabetic patients than in healthy controls (P< 0.001). Atherosclerotic changes were found in 34.0% and 71.4% of patients suffering from diabetes for < 5 and ≥5 years, respectively. Conclusion: This study suggests that TCD is a useful marker for the detection of diabetic cerebrovascular changes. The duration and type of diabetes were found to have an impact on the development of pathologic cerebrovascular changes. |
| Databáze: | Directory of Open Access Journals |
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