Efficacy of chemotherapy in elderly patients with unresectable pancreatic cancer: a multicenter review of 895 patients

Autor: Taira Kuroda, Teru Kumagi, Tomoyuki Yokota, Nobuaki Azemoto, Aki Hasebe, Hirotaka Seike, Mari Nishiyama, Nobu Inada, Naozumi Shibata, Hideki Miyata, Tomoe Kawamura, Yusuke Imai, Akiko Ueno-Toshimori, Yoshinori Tanaka, Takashi Terao, Yoshiki Imamura, Mitsuhito Koizumi, Hirofumi Yamanishi, Yoshinori Ohno, Yoichi Hiasa, on behalf of the Ehime Pancreato-Cholangiology (EPOCH) Study Group
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: BMC Gastroenterology, Vol 17, Iss 1, Pp 1-7 (2017)
Druh dokumentu: article
ISSN: 1471-230X
DOI: 10.1186/s12876-017-0623-8
Popis: Abstract Background The efficacy of chemotherapy for unresectable pancreatic cancer has improved. However, it is occasionally difficult to make treatment decisions for elderly patients. We reviewed the outcomes of elderly patients with unresectable pancreatic cancer by using a large cohort and evaluated whether they had received chemotherapy and the reason why. Methods Data for 895 pancreatic cancer patients who were treated using chemotherapy or best supportive care were analyzed considering demographics, clinical stage, treatment, and outcome. Data were analyzed using the chi-square test, Student t-test, or Mann-Whitney U-test, as appropriate. Outcomes were analyzed using the Kaplan-Meier method. Differences in survival were analyzed using the log-rank test. Results The median survival time was significantly shorter in elderly patients (≥65 years) than in younger patients (
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