CYP19A1 gene expression in the peripheral blood of Brazilian women with breast cancer relapse

Autor: Maria da Conceição Barros-Oliveira, Danylo Rafhael Costa-Silva, Larysse Cardoso Campos-Verdes, Renato de Oliveira Pereira, Rozirene Araújo Silva, Paulo de Tarso Moura-Borges, Emerson Brandão Sousa, André Luiz Pinho-Sobral, Pedro Vitor Lopes-Costa, Alesse Ribeiro dos Santos, Ione Maria Ribeiro Soares-Lopes, Jackeline Lopes Viana, Mariella de Almeida Melo, Fidelis Manes Neto, Eid Gonçalves Coelho, Maria do Socorro Pires e Cruz, Vladimir Costa-Silva, Luiz Henrique Gebrim, Benedito Borges Da Silva
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
Druh dokumentu: article
ISSN: 1471-2407
78451744
DOI: 10.1186/s12885-020-06978-z
Popis: Abstract Background The CYP19A1 gene, which encodes the enzyme responsible for androgen aromatization into estrogens, may play an important role in breast cancer aggressiveness. However, no study has evaluated CYP19A1 gene expression in the peripheral blood of women with relapsed breast cancer. Methods In this cross-sectional study, CYP19A1 gene expression was quantified by RT-PCR in the peripheral blood of 146 women with breast cancer who were first divided into two groups according to the expression of CYP19A1 (low and high); each group had 73 patients. Subsequently, women were divided into two groups: those without recurrence (control, n = 85) and those with recurrence (study, n = 61). Statistical analysis of the data was performed using ANOVA, the Mann-Whitney, Chi-square or Fisher’s exact test (p
Databáze: Directory of Open Access Journals
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