Investigation of the In Vitro Antioxidant Potential Of Polyphenolic-Rich Extract of Lam Stem Bark and Its Antidiabetic Activity In Streptozotocin-Induced Diabetic Rats
| Autor: | Basiru Olaitan Ajiboye PhD, Oluwafemi Adeleke Ojo PhD, Babatunji Emmanuel Oyinloye PhD, Mary Abiola Okesola MSc, Adeyonu Oluwatosin BSc, Aline Augusti Boligon PhD, Abidemi Paul Kappo PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Evidence-Based Integrative Medicine, Vol 25 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2515-690X 2515690X |
| DOI: | 10.1177/2515690X20916123 |
| Popis: | Artocarpus heterophyllus Lam (Moraceae) stem bark has been used locally in managing diabetes mellitus with sparse scientific information. This study investigates the in vitro antioxidant potential of polyphenolic-rich extract of A heterophyllus stem bark as well as its antidiabetic activity in streptozotocin-induced diabetic rats. Fifty male Wistar rats were used with the induction of diabetes by a single intraperitoneal injection of streptozotocin (45 mg/kg body weight) and were orally administered 400 mg/kg free and bound phenols of A heterophyllus stem bark. The animals were sacrificed on the 28th day of the experiment using the cervical dislocation method; antihyperglycemia and anti-inflammatory parameters were subsequently assessed. The polyphenolic extracts demonstrated antioxidant potentials (such as hydrogen peroxide and diphenyl-1-picrylhydrazyl), as well as strong inhibitory activity against amylase and glucosidase. There was a significant ( P < .05) increase in glycogen, insulin concentration, pancreatic β-cell scores (HOMA-β), antioxidant enzymes and hexokinase activities, as well as glucose transporter concentration in diabetic animals administered the extracts and metformin. Also, a significant ( P < .05) reduction in fasting blood glucose, lipid peroxidation, glucose-6-phosphatase, and all anti-inflammatory parameters were observed in diabetic rats administered the extracts and metformin. The extracts demonstrated antidiabetic potential, which may be useful in the management of diabetes mellitus |
| Databáze: | Directory of Open Access Journals |
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