A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response

Autor: G. Gambardella, G. Viscido, B. Tumaini, A. Isacchi, R. Bosotti, D. di Bernardo
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-29358-6
Popis: The impact of tumour heterogeneity on drug response in breast cancer is not fully understood. Here, the authors characterise cell lines from all main breast cancer subtypes using single-cell RNA-seq and train a deconvolution algorithm to predict drug responses in heterogeneous tumour cell populations.
Databáze: Directory of Open Access Journals
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