Platelet Microparticle Controversial Role in Cancer
| Autor: | Mahnaz Nazari, Ehsan Javandoost, Mehdi Talebi, Aliakbar Movassaghpour, Masoud Soleimani |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Advanced Pharmaceutical Bulletin, Vol 11, Iss 1, Pp 39-55 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2228-5881 2251-7308 |
| DOI: | 10.34172/apb.2021.005 |
| Popis: | Platelet-derived microparticles (PMPs) are a group of micrometer-scale extracellular vesicles released by platelets upon activation that are responsible for the majority of microvesicles found in plasma. PMPs’ physiological properties and functions have long been investigated by researchers. In this regard, a noticeable area of studies has been devoted to evaluating the potential roles and effects of PMPs on cancer progression. Clinical and experimental evidence conflictingly implicates supportive and suppressive functions for PMPs regarding cancer. Many of these functions could be deemed as a cornerstone for future considerations of PMPs usage in cancer targeted therapy. This review discusses what is currently known about PMPs and provides insights for new and possible research directions for further grasping the intricate interplay between PMPs and cancer. |
| Databáze: | Directory of Open Access Journals |
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