Immune‐mediated polyarthritis and anterior uveitis secondary to zonisamide administration in a dog with refractory epilepsy

Autor:	Paula Baya, Saya Press, Stephanie Istvan, Kaila Rizzo
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	adverse reactions epilepsy polyarthritis uveitis zonisamide Veterinary medicine SF600-1100
Zdroj:	Veterinary Medicine and Science, Vol 10, Iss 2, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2053-1095
DOI:	10.1002/vms3.1374
Popis:	Abstract The objective of this article is to describe a case of suspected zonisamide‐induced immune‐mediated polyarthritis (IMPA) and anterior uveitis in a dog. A 7‐year‐old male neutered Siberian Husky with a history of refractory idiopathic epilepsy was presented for cluster seizures. Following the addition of zonisamide to the antiepileptic regime, the dog developed new IMPA and anterior uveitis. Within a few weeks of discontinuation of the zonisamide, the dog's IMPA and anterior uveitis resolved. These immune‐mediated conditions were thus presumed to be an idiosyncratic reaction to zonisamide. To our knowledge, this is the first report of IMPA and anterior uveitis in dogs associated with zonisamide administration at its recommended dose.
Databáze:	Directory of Open Access Journals
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