Successful treatment of infliximab-induced psoriasiform skin lesions despite biologic therapy intensification in a paediatric patient with Crohn’s disease and primary sclerosing cholangitis
| Autor: | Agata Wasilewska, Małgorzata Chmielowska-Trybek, Małgorzata Sładek |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Pediatria Polska, Vol 96, Iss 2, Pp 143-147 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0031-3939 2300-8660 |
| DOI: | 10.5114/polp.2021.107400 |
| Popis: | Therapy with infliximab (IFX), a tumour necrosis factor-α (TNF-α) inhibitor, has been demonstrated to be highly effective in several immune-mediated inflammatory diseases including Crohn’s disease (CD) and psoriasis, both in adult and paediatric patients. With the increasingly widespread use and longer follow-up of IFX, one unexpected adverse effect that has been reported is the occurrence of psoriasis-like lesions, mainly during the maintenance therapy. The present report was aimed at describing a new case of IFX-induced psoriasis-like lesions in a 17-year-old boy with CD and primary sclerosing cholangitis (PSC), which was successfully treated with topical agents, despite IFX therapy intensification due to loss of the clinical response. |
| Databáze: | Directory of Open Access Journals |
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