Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs

Autor: Quentin R. V. Ferry, Radostina Lyutova, Tudor A. Fulga
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14633
Popis: Being able to regulate gene expression in a controllable manner is one of the promises of synthetic biology, and CRISPR-Cas9 is one of the tools being developed to achieve that goal. Here the authors develop an inducible CRISPR platform using an engineered guide RNA.
Databáze: Directory of Open Access Journals