Neurological Outcomes of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer: A Systematic Review and Meta-Analysis

Autor: Katsuyoshi Suzuki MSc, Shinichiro Morishita PhD, Jiro Nakano PhD, Taro Okayama BSc, Junichiro Inoue PhD, Takashi Tanaka PhD, Takuya Fukushima PhD
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Integrative Cancer Therapies, Vol 22 (2023)
Druh dokumentu: article
ISSN: 1552-695X
15347354
DOI: 10.1177/15347354231185110
Popis: Background: This systematic review and meta-analysis aimed to determine whether chemotherapy-induced peripheral neuropathy (CIPN) affects the risk of falls and physical function in patients with cancer. Methods: A literature search was conducted in the CINAHL, Scopus, and PubMed databases for articles published from January 1950 to April 2022. Seven review authors retrieved studies using predetermined eligibility criteria, extracted the data, and evaluated the quality. Results: Nine studies were included in the analysis. Patients with CIPN had a significantly higher risk of falls than those without CIPN (risk ratio = 1.38, 95% confidence interval [CI] =1.18-1.62). Patients with CIPN had lower grip strength (standardized mean difference [SMD] =−0.42, 95% CIs = −0.70 to −0.14, P = .003), longer chair stand time (SMD = 0.56, 95% CIs = −0.01 to 1.17, P = .05), worse timed up and go test time (SMD = 0.79, 95% CIs = 0.41 to 1.17, P
Databáze: Directory of Open Access Journals