| Autor: |
Kentaro Wakamatsu, Nobuhiko Nagata, Hiroyuki Kumazoe, Makiko Hara, Satomi Asai, Naotaka Noda, Ruriko Kiyotani, Izumi Fukui, Miyoko Tatsuta, Katsuyuki Katahira, Takashi Akasaki, Sanae Maki, Kouta Miyamoto, Junji Otsuka, Miiru Izumi, Masayuki Kawasaki, Hozumi Yamada |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-10 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2466 |
| DOI: |
10.1186/s12890-024-03224-1 |
| Popis: |
Abstract Background The serum markers Krebs von den Lungen-6 (KL-6), surfactant protein A (SP-A), and surfactant protein D (SP-D) have been used for the diagnosis, differential diagnosis, and prognosis prediction of interstitial pneumonia. However, the significance of measuring the serum and bronchoalveolar lavage fluid (BALF) KL-6, SP-D, and SP-A levels in predicting the prognosis of chronic fibrosing interstitial pneumonia (CFIP), idiopathic pulmonary fibrosis, and idiopathic nonspecific interstitial pneumonia remains unclear. We aimed to clarify the significance of measuring the serum and BALF KL-6, SP-A, and SP-D levels in predicting the prognosis of patients with CFIP. Methods Among 173 patients who were diagnosed with CFIP between September 2008 and February 2021, 39 who underwent bronchoalveolar lavage were included in this study. Among these, patients experiencing an annual decrease in forced vital capacity (FVC) of ≥10% or those facing challenges in undergoing follow-up pulmonary function tests owing to significant deterioration in pulmonary function were categorized as the rapidly progress group. Conversely, individuals with an annual decrease in the FVC of |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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