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Temesgen Baylie,1 Tiget Ayelgn,2 Markeshaw Tiruneh,2 Kibur Hunie Tesfa2 1Department of Biomedical Science, School of Medicine, Debre Markos University, Debre Markos, Ethiopia; 2Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Temesgen Baylie, Department of Biomedical Science, School of Medicine, Debre Markos University, Debre Markos, Ethiopia, Tel +251 9 38219824, Email josybaylie38@gmail.comAbstract: Obesity is defined as an abnormal or excessive accumulation of fat that increases the burden of different chronic diseases in the population. It has reached epidemic proportions and is a major risk factor for a variety of diseases, including hypertension, cardiovascular disease, type 2 diabetes, dyslipidaemia, atherosclerosis, and some malignancies. Weight gain is a result of excessive energy intake compared to energy expenditure (energy loss from metabolism and physical exercise). A ketogenic diet has a more useful effect on obesity than other diets. A ketogenic diet is a low-carbohydrate, high-fat, moderate-protein diet that induces the production of ketone bodies by mimicking the breakdown of a fasting state. The mechanism behind the ketogenic diet is still unknown, although it obviously helps people with obesity lose weight. Several pathways for the ketogenic diet effect on weight loss have been hypothesized by researchers, including reduced appetite due to effects on appetite control hormones and a possible direct appetite suppressant action of ketone bodies; reduced lipogenesis and increased lipolysis; greater metabolic efficiency; and increased metabolic costs.Keywords: obesity, ketogenic diet, Ketone Body, metabolic disorder |
