Exposure to tris(2-butoxyethyl) phosphate induces abnormal sperm morphology and testicular histopathology in male rats

Autor: Hsiu-Yung Pan, Fu-Jen Cheng, Kuo-Chen Huang, Chia-Te Kung, Wan-Ting Huang, Huey-Ling You, Shau-Hsuan Li, Chin-Chou Wang, Wen-Chin Lee, Ping-Chi Hsu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Ecotoxicology and Environmental Safety, Vol 241, Iss , Pp 113718- (2022)
Druh dokumentu: article
ISSN: 0147-6513
DOI: 10.1016/j.ecoenv.2022.113718
Popis: Tris(2-butoxyethyl) phosphate (TBEP) is one of the most abundant organophosphate flame retardants in the environment. This study aimed to evaluate the effect of TBEP exposure during adolescence on male reproductive function in adult rats. Male Sprague–Dawley rats were treated with 20 and 200 mg/kg body weight of TBEP or corn oil from postnatal day (PND) 42 to PND 105. A significant increase in the proportion of sperm with abnormal morphology (flattened head and bent tail) and superoxide anion (O2-.) production in the sperm of the 200 mg/kg treated group was observed (p
Databáze: Directory of Open Access Journals