| Autor: |
Tiffany S. Ko, Constantine D. Mavroudis, Ryan W. Morgan, Wesley B. Baker, Alexandra M. Marquez, Timothy W. Boorady, Mahima Devarajan, Yuxi Lin, Anna L. Roberts, William P. Landis, Kobina Mensah-Brown, Vinay M. Nadkarni, Robert A. Berg, Robert M. Sutton, Arjun G. Yodh, Daniel J. Licht, Wensheng Guo, Todd J. Kilbaugh |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-83270-5 |
| Popis: |
Abstract Neurologic injury is a leading cause of morbidity and mortality following pediatric cardiac arrest. In this study, we assess the feasibility of quantitative, non-invasive, frequency-domain diffuse optical spectroscopy (FD-DOS) neuromonitoring during cardiopulmonary resuscitation (CPR), and its predictive utility for return of spontaneous circulation (ROSC) in an established pediatric swine model of cardiac arrest. Cerebral tissue optical properties, oxy- and deoxy-hemoglobin concentration ([HbO2], [Hb]), oxygen saturation (StO2) and total hemoglobin concentration (THC) were measured by a FD-DOS probe placed on the forehead in 1-month-old swine (8–11 kg; n = 52) during seven minutes of asphyxiation followed by twenty minutes of CPR. ROSC prediction and time-dependent performance of prediction throughout early CPR ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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