Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Autor:	Irene Fernández-Barahona, María Muñoz-Hernando, Jesus Ruiz-Cabello, Fernando Herranz, Juan Pellico
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	iron oxide nanoparticles magnetic resonance imaging positive contrast agents Inorganic chemistry QD146-197
Zdroj:	Inorganics, Vol 8, Iss 4, p 28 (2020)
Druh dokumentu:	article
ISSN:	2304-6740
DOI:	10.3390/inorganics8040028
Popis:	Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers have also exploited their application as positive (T1) contrast agents to overcome the limitation of traditional Gd3+ contrast agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over the size, morphology and surface of the particles. In this review, we summarise the reported T1 iron oxide nanoparticles and critically revise their properties, synthetic protocols and application, not only in MRI but also in multimodal imaging. In addition, we briefly summarise the most important nanoparticulate Gd and Mn agents to evaluate whether T1 iron oxide nanoparticles can reach Gd/Mn contrast capabilities.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3578b44e1d274773859c5e689375fe0b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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