Survival analysis of female dogs with mammary tumors after mastectomy: epidemiological, clinical and morphological aspects

Autor: Maria Luíza de M. Dias, Joanlise M. Leon Andrade, Márcio B. de Castro, Paula D. Galera
Jazyk: English<br />Portuguese
Rok vydání: 2016
Předmět:
Zdroj: Pesquisa Veterinária Brasileira, Vol 36, Iss 3, Pp 181-186 (2016)
Druh dokumentu: article
ISSN: 1678-5150
0100-736X
DOI: 10.1590/S0100-736X2016000300006
Popis: Abstract: Mammary gland tumors are the most common type of tumors in bitches but research on survival time after diagnosis is scarce. The purpose of this study was to investigate the relationship between survival time after mastectomy and a number of clinical and morphological variables. Data was collected retrospectively on bitches with mammary tumors seen at the Small Animal Surgery Clinic Service at the University of Brasília. All subjects had undergone mastectomy. Survival analysis was conducted using Cox's proportional hazard method. Of the 139 subjects analyzed, 68 died and 71 survived until the end of the study (64 months). Mean age was 11.76 years (SD=2.71), 53.84% were small dogs. 76.92% of the tumors were malignant, and 65.73% had both thoracic and inguinal glands affected. Survival time in months was associated with age (hazard rate ratios [HRR] =1.23, p-value =1.4x10-4), animal size (HRR between giant and small animals =2.61, p-value =0.02), nodule size (HRR =1.09, p-value =0.03), histological type (HRR between solid carcinoma and carcinoma in a mixed tumor =2.40, p-value =0.02), time between diagnosis and surgery (TDS, with HRR =1.21, p-value =2.7x10-15), and the interaction TDS*follow-up time (HRR =0.98, p-value =1.6x10-11). The present study is one of the few on the subject matter. Several important covariates were evaluated and age, animal size, nodule size, histological type, TDS and TDS*follow up time were identified as significantly associated to survival time.
Databáze: Directory of Open Access Journals
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