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Abstract Background The autoimmune disease Sjogren's syndrome (SS) is often characterized by salivary changes that may affect swallowing. No known study has investigated the association between salivary biomarkers and perceptions of swallowing in individuals with SS. Our objectives were to explore: (1) the operational feasibility of investigating saliva volume and composition, along with perceptions of swallowing, in those with and without SS; and (2) the relationship between saliva composition and perceptions of oral dryness, swallowing, and quality of life. Methods We conducted a prospective, case–control feasibility study, collecting feasibility data (recruitment rate and optimal saliva collection methods) and whole mouth saliva samples (unstimulated and stimulated). We measured total protein content and conducted sialochemical (α‐amylase, cortisol, C‐reactive protein [CRP], and mucins), sialometric (flow rate), and perceptual (oral dryness and swallowing‐related quality of life [SWAL‐QOL]) assessments. Our exploratory analyses focused on the main and fixed effects. We summarized all data descriptively, comparing: (a) outcomes between groups (t tests or Mann–Whitney U) and (b) salivary and perceptual data across participants (partial least‐squares correlation [PLSC]). Results We enrolled 12 (N) participants (6 per group), all providing analyzable saliva. Cases had lower flow rate (p = 0.003) and higher total protein, cortisol, and CRP concentrations (p |
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