Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury
| Autor: | Hui-Fang Song, MD, PhD, Sheng He, MD, PhD, Shu-Hong Li, MD, MSc, Wen-Juan Yin, MD, MSc, Jun Wu, MD, MSc, Jian Guo, MD, PhD, Zheng-Bo Shao, MD, PhD, Xiao-Yan Zhai, MD, PhD, Hui Gong, MD, PhD, Li Lu, MD, PhD, Fang Wei, MD, PhD, Richard D. Weisel, MD, Jun Xie, MD, PhD, Ren-Ke Li, MD, PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 702-716 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2452-302X 98745778 |
| DOI: | 10.1016/j.jacbts.2017.07.014 |
| Popis: | Reduced regenerative capacity of aged stem cells hampers the benefits of autologous cell therapy for cardiac regeneration. This study investigated whether neuron-derived neurotrophic factor (NDNF) could rejuvenate aged human bone marrow (hBM)- multipotent mesenchymal stromal cells (MSCs) and whether the rejuvenated hBM-MSCs could improve cardiac repair after ischemic injury. Over-expression of NDNF in old hBM-MSCs decreased cell senescence and apoptosis. Engraftment of NDNF over-expressing old hBM-MSCs into the ischemic area of mouse hearts resulted in improved cardiac function after myocardial infarction, while promoting implanted stem cell survival. Our findings suggest NDNF could be a new factor to rejuvenate aged stem cells and improve their capability to repair the aged heart after injury. |
| Databáze: | Directory of Open Access Journals |
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