| Autor: |
Moses W. Bariweni, Oboma I. Yibala, Raymond I. Ozolua |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacy & Pharmacognosy Research, Vol 6, Iss 1, Pp 1-16 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
0719-4250 |
| Popis: |
Context: Pavetta crassipes (K. Schum) is used in ethnomedicine for the management of various ailments and food without scientific report of its toxicity profile. Aims: To evaluate the toxicological effects of Pavetta crassipes leaves in rodents. Methods: The leaves of Pavetta crassipes were collected from the suburbs of Abuja, Nigeria, dried and powdered using an electric mill. Hot aqueous extraction was done using 250 g of the powdered leaf in 1000 mL distilled water. Lethal dose 50 (LD50) determination was done in mice (intraperitoneally) and rats (orally), twenty-eight-day toxicity testing in rats at doses of 400, 800 and 1600 mg/kg was also done using the aqueous extract. Biochemical, hematological and histological effects were evaluated using standard procedures. Results: The aqueous leaf extract of Pavetta crassipes (AE) appears safe as the LD50 for intraperitoneal route in mice and oral route in rats was greater than 5000 mg/kg. The results of the 28-day repeated exposure test produced no mortality or adverse effects on the body weights and organ/body weight ratio of rats. Histological changes occurred in the kidneys at 800 and 1600 mg/kg. There was a significant (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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