Genomic features and prevalence of Ruminococcus species in humans are associated with age, lifestyle, and disease
| Autor: | Vincenzo Valentino, Francesca De Filippis, Roberto Marotta, Edoardo Pasolli, Danilo Ercolini |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Cell Reports, Vol 43, Iss 12, Pp 115018- (2024) |
| Druh dokumentu: | article |
| ISSN: | 2211-1247 45737789 |
| DOI: | 10.1016/j.celrep.2024.115018 |
| Popis: | Summary: The genus Ruminococcus is dominant in the human gut, but higher levels of some species, such as R. gnavus, R. torques, and R. bromii, have been linked to health or disease. In this study, we analyzed >9,000 Ruminococcus metagenome-assembled genomes (MAGs) reconstructed from >5,000 subjects and revealed significant links between the prevalence of some species/subspecies and geographic origin, age, lifestyle, and disease, with subspecies prevalent in specific subpopulations showing divergent metabolic potential. Furthermore, Ruminococcus species from Lachnospiraceae encoded for carbohydrate-active enzymes (CAZy) potentially involved in the metabolism of human N- and O-glycans, whereas those from Oscillospiraceae appear to be more adapted toward fiber metabolism. These new findings contribute to elucidating the potential functional role of Ruminococcus in specific lifestyles and diseases and to decipher the diversity and the adaptation of members of this genus to the human gut. |
| Databáze: | Directory of Open Access Journals |
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