Determination of ertapenem in plasma and ascitic fluid by UHPLC-MS/MS in cirrhotic patients with spontaneous bacterial peritonitis

Autor:	Rigo-Bonnin Raúl, Amador Alberto, Núñez-Gárate María, Mas-Bosch Virgínia, Padullés Ariadna, Cobo-Sacristán Sara, Castellote José
Jazyk:	English<br />Spanish; Castilian
Rok vydání:	2023
Předmět:	ertapenem ascitic fluid plasma uhplc-ms/ms Medical technology R855-855.5
Zdroj:	Advances in Laboratory Medicine, Vol 5, Iss 2, Pp 173-180 (2023)
Druh dokumentu:	article
ISSN:	2628-491X 2023-0168
DOI:	10.1515/almed-2023-0168
Popis:	Spontaneous bacterial peritonitis is a frequent severe complication in cirrhotic patients with ascites. Carbapenem antibiotics are currently the treatment of choice for patients with hospital-acquired or healthcare-related infections. However, there is limited evidence available on the efficacy of ertapenem in cirrhotic patients with spontaneous bacterial peritonitis. As a result, the pharmacokynetics and pharmacodynamics of this antibiotic are still unknown. The objective of this study was to develop and validate measurement procedures based on liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to determine ertapenem concentrations in plasma and ascitic fluid.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3509754814b74df8aa943a6000506a97 Zobrazit plný text záznamu View record in DOAJ