Single Cell Sequencing of the Pineal Gland: The Next Chapter

Autor: Steven L. Coon, Cong Fu, Steven W. Hartley, Lynne Holtzclaw, Joseph C. Mays, Michael C. Kelly, Matthew W. Kelley, James C. Mullikin, Martin F. Rath, Luis E. Savastano, David C. Klein
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Frontiers in Endocrinology, Vol 10 (2019)
Druh dokumentu: article
ISSN: 1664-2392
DOI: 10.3389/fendo.2019.00590
Popis: The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of entire transcriptomes and, most recently, the sequencing of the transcriptome of individual cells. Identification of at least nine distinct cell types in the rat pineal gland has been made possible, allowing identification of the precise cells of origin and expression of transcripts for the first time. Here the history and current state of knowledge generated by these transcriptomic efforts is reviewed, with emphasis on the insights suggested by the findings.
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