Experimental Study of Immunological Activity of Live Plague Vaccine Subjected to Extreme Temperature
| Autor: | D. A. Budyka, A. A. Fisun, E. L. Rakitina, N. V. Abzayeva |
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| Jazyk: | ruština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Эпидемиология и вакцинопрофилактика, Vol 14, Iss 4, Pp 74-79 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2073-3046 2619-0494 |
| DOI: | 10.31631/2073-3046-2015-14-4-74-79 |
| Popis: | The study has resulted in the comparative estimate of the immunological activity of the preparations (LPV) with optimal storage mode and after exposure to extreme temperature (37 ± 1 °С) for 6 days, followed by storage at (4 ± 2 °С). Data obtained during the study indicate an identical immune response. After-heat LPV sample did not reduce the ability to exercise immunological activity during the three-year storage (shelf-life of the drug). When the animals vaccination in this group, total number of T-lymphocytes are increased and signs of humoral immunity are shown earlier. Thus, we can predict more labile conditions on the transportation of live bacterial vaccine without compromising its characteristics. |
| Databáze: | Directory of Open Access Journals |
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