| Autor: |
Hironori Fujiwara, Ako Kogure, Masahiro Sakamoto, Tohru Yamakuni, Yoshihiro Mimaki, Kiyoshi Murata, Nobuyuki Hitomi, Kikuji Yamaguchi, Yasushi Ohizumi |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 116, Iss 4, Pp 384-387 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.11001SC |
| Popis: |
Abstract.: To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells. Moreover, CRE-mediated transcriptional activity by RJ was enhanced by nobiletin. U0126, a MEK inhibitor, inhibited CRE-mediated transcription by combining RJ plus nobiletin without affecting transcription by RJ alone. These results suggest that RJ stimulates CRE-mediated transcription via an ERK-independent cascade, whereas the increasing CRE-mediated transcriptional effect by nobiletin is dependent on ERK phosphorylation. Combining RJ plus nobiletin may activate effectively neuronal functions via enhancement of CRE-mediated transcription. Keywords:: honeybee royal jelly, CRE-mediated transcription, Alzheimer’s disease |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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