Should the management of high grade cervical squamous intraepithelial lesion (HSIL) be different in HIV-positive women?

Autor: Christine Gilles, Maude Velghe-lenelle, Yannick Manigart, Déborah Konopnicki, Serge Rozenberg
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: AIDS Research and Therapy, Vol 18, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 1742-6405
DOI: 10.1186/s12981-021-00371-x
Popis: Abstract Background This study compares the management and outcome of high grade squamous intraepithelial lesions (HSIL) in HIV-positive and -negative women and identifies risk factors for treatment failure. Methods This retrospective, controlled study includes 146 HIV-positive women, matched for HSIL, age and year of diagnosis, with 146 HIV-negative women. Differences were analysed using parametric and non-parametric tests and Kaplan–Meier survival curves. A binary logistic regression was used to assess risk factors for treatment failure. Results Persistence of cervical disease was observed most frequently in HIV-positive women (42 versus 17%) (p
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