| Autor: |
Isabelle Vock, Lisandra Aguilar-Bultet, Nina Khanna, Adrian Egli, Elisabeth Wehrle-Wieland, Pranita D. Tamma, Sarah Tschudin Sutter |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Swiss Medical Weekly, Vol 154, Iss 10 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1424-3997 |
| DOI: |
10.57187/s.3904 |
| Popis: |
AIMS: Aminoglycoside resistance is frequently detected in extended-spectrum-beta-lactamase (ESBL)-producing Enterobacterales (ESBL-PE), questioning the appropriateness of aminoglycosides as empiric therapy in patients with suspected ESBL-PE infections. Therefore, we aimed to evaluate the frequency of aminoglycoside resistance in patients harbouring ESBL-PE and identify patient-related risk factors associated with aminoglycoside resistance to facilitate early detection of at-risk patients. METHODS: This retrospective single-centre cohort study included hospitalised patients aged ≥18 years with an ESBL-PE-positive sample between January 2016 and December 2018. Aminoglycoside resistance was defined according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoints for Enterobacterales for the current year of testing. RESULTS: Five hundred forty-four patients met the eligibility criteria, of which 240 (44.1%) harboured aminoglycoside-resistant ESBL strains. Identification of ESBL-Klebsiella pneumoniae was significantly associated with aminoglycoside resistance (odds ratio [OR] = 2.64, 95% confidence interval [CI] = 1.65–4.21, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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