Synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction

Autor: Bakherad Mohammad, Keivanloo Ali, Amin Amir H., Farkhondeh Amir
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Heterocyclic Communications, Vol 25, Iss 1, Pp 122-129 (2019)
Druh dokumentu: article
ISSN: 2191-0197
DOI: 10.1515/hc-2019-0016
Popis: An efficient method has been developed for the synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction in ethanol at 50°C. A broad range of aromatic azides were successfully reacted with n-propynylated benzimidazole via copper-catalyzed azide-alkyne cycloaddition reactions in the absence of a ligand. This method offers many advantages including short reaction times, low cost, and simple purification procedures.
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