Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

Autor: Tai-Ran Kang, Ting-Ting Yan, Jie Liu, Hong-Bao Sun, Yong-Mei Xie, Yu-Qin Yao
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Molecules, Vol 16, Iss 10, Pp 8745-8757 (2011)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules16108745
Popis: An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
Databáze: Directory of Open Access Journals