Genomic Variation-Mediating Fluconazole Resistance in Yeast

Autor:	Wen-Yao Wang, Hong-Qing Cai, Si-Yuan Qu, Wei-Hao Lin, Cheng-Cheng Liang, Hao Liu, Ze-Xiong Xie, Ying-Jin Yuan
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	antifungal resistance fluconazole yeast genomic variations aneuploidy loss of heterozygosity Microbiology QR1-502
Zdroj:	Biomolecules, Vol 12, Iss 6, p 845 (2022)
Druh dokumentu:	article
ISSN:	2218-273X
DOI:	10.3390/biom12060845
Popis:	Fungal infections pose a serious and growing threat to public health. These infections can be treated with antifungal drugs by killing hazardous fungi in the body. However, the resistance can develop over time when fungi are exposed to antifungal drugs by generating genomic variations, including mutation, aneuploidy, and loss of heterozygosity. The variations could reduce the binding affinity of a drug to its target or block the pathway through which drugs exert their activity. Here, we review genomic variation-mediating fluconazole resistance in the yeast Candida, with the hope of highlighting the functional consequences of genomic variations for the antifungal resistance.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c34edb6b3b73437b884694378b419a1f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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