From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound
| Autor: | Hamaidia, M., Barez, PY., Carpentier, A., Lebecque, S., Miazek, K., Paul, A., Sriramareddy, SN., Staumont, B., Danthine, S., Deleu, M., Frederich, M., De Pauw, E., Delaplace, P., Delvigne, F., Goffin, D., Ongena, M., Duysinx, B., Louis, R., Cosse, JP., Willems, L. |
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| Jazyk: | English<br />French |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Biotechnologie, Agronomie, Société et Environnement, Vol 20, Iss s1, Pp 314-320 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1370-6233 1780-4507 |
| Popis: | Introduction. Over the centuries, bio-sourced compounds isolated from plants, insects and microorganisms have been a potent source of drugs for the treatment of human diseases. Literature. Bio-sourced extracts offer a wide diversity of compounds with a large number of potentially beneficial effects in humans. Serendipity has frequently played a key role in the discovery of new medicines. The canonical discovery of penicillin required both chance and a prepared mind to understand and exploit its potential for the treatment of human infections. Nowadays, most anti-cancer drugs currently in clinical use were at least partly discovered by a "fortunate happenstance". Conclusions. In this review, we recapitulate the story of one of these compounds, 2-propylpentanoic acid, derived from the Valeriana officinalis flowering plant and its path to validation as a cancer treatment. |
| Databáze: | Directory of Open Access Journals |
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