Modelling the tumor microenvironment in vitro in prostate cancer: current and future perspectives

Autor: Kedi Yuan, Xinxing Du, Liang Dong, Jiahua Pan, Wei Xue
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: View, Vol 5, Iss 5, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2688-268X
2688-3988
20240074
DOI: 10.1002/VIW.20240074
Popis: Abstract Prostate cancer is the most common cancer in over 50% of countries and the third most common malignancy worldwide. The tumor microenvironment includes the non‐cancerous cells and components present in the tumor, including the molecules they produce and release. Prostate cancer proliferation, angiogenesis, metastasis, and drug resistance are closely associated with the tumor microenvironment. With the continuous development of in vitro tumor models, they have gradually become important tools for recapitulating in vivo parental tumors and studying the reciprocal interactions between tumors and their microenvironment. In this perspective, we describe the significant in vitro models of prostate cancer, analyze the research results on incorporating the tumor microenvironment into these models, and compare their advantages and disadvantages. Furthermore, we highlight the future developmental direction of in vitro prostate cancer model research according to the hotspots of in vitro model research in other cancer types to facilitate precision medicine in prostate cancer.
Databáze: Directory of Open Access Journals
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