What Single Cell RNA Sequencing Has Taught Us about Chronic Obstructive Pulmonary Disease
| Autor: | Don D. Sin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Tuberculosis and Respiratory Diseases, Vol 87, Iss 3, Pp 252-260 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1738-3536 2005-6184 98282557 |
| DOI: | 10.4046/trd.2024.0001 |
| Popis: | Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide and is the 3rd leading cause of mortality. It is a heterogeneous disorder with multiple endophenotypes, each driven by specific molecular networks and processes. Therapeutic discovery in COPD has lagged behind other disease areas owing to a lack of understanding of its pathobiology and scarcity of biomarkers to guide therapies. Single cell RNA sequencing (scRNA-seq) is a powerful new tool to identify important cellular and molecular networks that play a crucial role in disease pathogenesis. This paper provides an overview of the scRNA-seq technology and its application in COPD and the lessons learned to date from scRNA-seq experiments in COPD. |
| Databáze: | Directory of Open Access Journals |
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