| Autor: |
Mingming Wu, Xiao Zhang, Weijie Zhang, Yi Shiou Chiou, Wenchang Qian, Xiangtian Liu, Min Zhang, Hong Yan, Shilan Li, Tao Li, Xinghua Han, Pengxu Qian, Suling Liu, Yueyin Pan, Peter E. Lobie, Tao Zhu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-29018-9 |
| Popis: |
The contribution of breast cancer stem cells (BCSCs) to metastasis needs further elucidation. Here, the authors show that BCSCs secrete DKK1 to protect metastasizing cancer cells from ferroptosis via upregulation of SLC7A11, and further show that the combination of a ferroptosis inducer with a DKK1 inhibitor reduces metastasis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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