Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development

Autor:	Binu Jacob, Alicia Vogelaar, Enrique Cadenas, Julio A. Camarero
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	cyclotides drug design backbone cyclized polypeptides protein–protein interactions Cys-rich peptides Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 19, p 6430 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27196430
Popis:	This review provides an overview of the properties of cyclotides and their potential for developing novel peptide-based therapeutics. The selective disruption of protein–protein interactions remains challenging, as the interacting surfaces are relatively large and flat. However, highly constrained polypeptide-based molecular frameworks with cell-permeability properties, such as the cyclotide scaffold, have shown great promise for targeting those biomolecular interactions. The use of molecular techniques, such as epitope grafting and molecular evolution employing the cyclotide scaffold, has shown to be highly effective for selecting bioactive cyclotides.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/34c3c76f25e14e01bb606e2f9364b9bb Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.