| Autor: |
Anoka A. Njan, Solomon O. Olaoye, Saheed O. Afolabi, Benjamen C Ejimkonye, Anthonia Soje, Olufunke E. Olorundare, Ezekiel O. Iwalewa |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Toxicology Reports, Vol 6, Iss , Pp 496-504 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2214-7500 |
| DOI: |
10.1016/j.toxrep.2019.04.009 |
| Popis: |
This study evaluates the reproductive toxicity of ethyl acetate and butanolic fractions from crude methanolic leaf extract of Ocimum gratissimum in male Wistar rats. Acute toxicity was assessed to determine the safety dose, Sub-chronic reproductive toxicity studies were carried out by administering daily 25, 100 and 400 mg/kg body weight doses of the fractions to respective group of animals and 1 ml of normal saline daily for the control group for 28 days. Blood, epididymis and testes were harvested for reproductive hormones, sperm parameters, and histopathologic analysis respectively. There was significant (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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