| Autor: |
Robert N. Fetcho, Baila S. Hall, David J. Estrin, Alexander P. Walsh, Peter J. Schuette, Jesse Kaminsky, Ashna Singh, Jacob Roshgodal, Charlotte C. Bavley, Viraj Nadkarni, Susan Antigua, Thu N. Huynh, Logan Grosenick, Camille Carthy, Lauren Komer, Avishek Adhikari, Francis S. Lee, Anjali M. Rajadhyaksha, Conor Liston |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-023-37460-6 |
| Popis: |
Abstract Social hierarchies exert a powerful influence on behavior, but the neurobiological mechanisms that detect and regulate hierarchical interactions are not well understood, especially at the level of neural circuits. Here, we use fiber photometry and chemogenetic tools to record and manipulate the activity of nucleus accumbens-projecting cells in the ventromedial prefrontal cortex (vmPFC-NAcSh) during tube test social competitions. We show that vmPFC-NAcSh projections signal learned hierarchical relationships, and are selectively recruited by subordinate mice when they initiate effortful social dominance behavior during encounters with a dominant competitor from an established hierarchy. After repeated bouts of social defeat stress, this circuit is preferentially activated during social interactions initiated by stress resilient individuals, and plays a necessary role in supporting social approach behavior in subordinated mice. These results define a necessary role for vmPFC-NAcSh cells in the adaptive regulation of social interaction behavior based on prior hierarchical interactions. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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