When Immunity Kills: The Lessons of SARS-CoV-2 Outbreak
| Autor: | Yassine Taoufik, Marie-Ghislaine de Goër de Herve, Stéphanie Corgnac, Antoine Durrbach, Fathia Mami-Chouaib |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1664-3224 35426446 |
| DOI: | 10.3389/fimmu.2021.692598 |
| Popis: | Since its emergence at the end of 2019, SARS-CoV-2 has spread worldwide at a very rapid pace. While most infected individuals have an asymptomatic or mild disease, a minority, mainly the elderly, develop a severe disease that may lead to a fatal acute respiratory distress syndrome (ARDS). ARDS results from a highly inflammatory immunopathology process that includes systemic manifestations and massive alveolar damages that impair gas exchange. The present review summarizes our current knowledge in the rapidly evolving field of SARS-CoV-2 immunopathology, emphasizing the role of specific T cell responses. Indeed, accumulating evidence suggest that while T-cell response directed against SARS-CoV-2 likely plays a crucial role in virus clearance, it may also participate in the immunopathology process that leads to ARDS. |
| Databáze: | Directory of Open Access Journals |
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