| Autor: |
Jani Reddy Bolla, Chih-Chia Su, Sylvia V Do, Abhijith Radhakrishnan, Nitin Kumar, Feng Long, Tsung-Han Chou, Jared A Delmar, Hsiang-Ting Lei, Kanagalaghatta R Rajashankar, William M Shafer, Edward W Yu |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 9, Iss 6, p e97903 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0097903 |
| Popis: |
Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually-transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains, which are growing at an alarming rate. The MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here report the crystal structure of the inner membrane MtrD multidrug efflux pump, which reveals a novel structural feature that is not found in other RND efflux pumps. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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